Timothy A. Springer, Ph.D.

Dr. Timothy Springer is a 1971 Phi Beta Kappa graduate of the University of California, Berkeley, and earned his Ph.D. in molecular biology and biochemistry from Harvard University in 1976 under Dr. Jack Strominger’s mentorship. In 1977, after a fellowship with César Milstein at the University of Cambridge, England, he began as an Assistant Professor at Harvard Medical School (HMS). Tim has been Latham Family Professor at HMS since 1989. He also holds appointments in the Departments of Biological Chemistry and Molecular Pharmacology and of Medicine at HMS and in the Program in Cellular and Molecular Medicine at Boston Children’s Hospital. Tim has been a pioneer in the investigation of leukocyte adhesion molecules. His work has identified many of the major known adhesion receptors, particularly in the integrin and Ig family classes, and has elucidated their structure, biochemical activity, binding relationships, and in vivo function. Many of the discoveries from his lab have been instrumental in the development of therapeutics for autoimmune and immune-related disorders such as psoriasis, Crohn’s disease, and ulcerative colitis. More recently, his research has blossomed in a broad range of fields and topics: with a focus on how force interacts with protein conformational change to activate integrins, von Willebrand factor, transforming growth factor-β, bone morphogenetic proteins, and adhesins on malaria sporozoites. He is a member of the National Academy of Sciences and his honors include the Crafoord Prize, the American Association of Immunologists Meritorious Career Award, and the Stratton Medal from the American Society of Hematology. Read More »