Publications
Structural Evidence for Loose Linkage between Ligand Binding and Kinase Activation in the Epidermal Growth Factor Receptor. Mol Cell Biol. 30, 22, 5432-43 (2010).Abstract
A mechanically stabilized receptor-ligand flex-bond important in the vasculature. Nature 466, 7309, 992-5 (2010).Abstract
Requirement of open headpiece conformation for activation of leukocyte integrin αXβ2. Proc Natl Acad Sci USA 107, 14727-32 (2010).Abstract
Engineering of single Ig superfamily domain of intercellular adhesion molecule 1 (ICAM-1) for native fold and function. J Biol Chem. 285, 15906-15 (2010).Abstract
A cation-π interaction regulates ligand binding affinity and signaling of integrin α4β7. Proc Natl Acad Sci USA 107, 21388-21393 (2010).Abstract
Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor. Proc Natl Acad Sci USA 106, 23, 9226-31 (2009).Abstract
Transmission of Allostery through the Lectin Domain in Selectin-Mediated Cell Adhesion. Proc Natl Acad Sci USA 106, 1, 85-90 (2009).Abstract
Rationally designed integrin beta3 mutants stabilized in the high affinity conformation. J Biol Chem. 284, 6, 3917-24 (2009).Abstract
Mechanoenzymatic cleavage of the ultralarge vascular protein, von Willebrand Factor. Science 324, 5932, 1330-4 (2009).Abstract
The novel S527F mutation in the integrin β3 chain induces a high affinity αIIbβ3 receptor by hindering adoption of the bent conformation. J Biol Chem. 284, 22, 14917-14918 (2009).Abstract
Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1. Proc Natl Acad Sci USA 106, 43, 18345-50 (2009).Abstract
The structure of a receptor with two associating transmembrane domains on the cell surface: integrin αIIbβ3. Mol Cell. 34, 2, 234-249 (2009).Abstract
Functional and Structural Stability of the Epidermal Growth Factor Receptor in Detergent Micelles and Phospholipid Nanodiscs. Biochemistry 47, 39, 10314-23 (2008).Abstract
Structural basis for distinctive recognition of fibrinogen by the platelet integrin αIIbβ3. J Cell Biol. 182, 4, 791-800 (2008).Abstract
Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration. J Exp Med. 205, 1, 195-205 (2008).Abstract
Trans-cellular migration: cell-cell contacts get intimate. Curr. Opin. Cell Biol. 20, 533-40 (2008).Abstract