Publications
Rational design of ICAM-1 variants for antagonizing integrin LFA-1-dependent adhesion. J Biol Chem. 281, 8, 5042-5049 (2006).Abstract
Regulation of outside-in signaling by the β2 I domain of integrin αLβ2. Proc Natl Acad Sci USA 103, 35, 13062-13067 (2006).Abstract
Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin αXβ2. Proc Natl Acad Sci USA 102, 5, 1614-1619 (2005).Abstract
Contribution of N-linked glycans to the conformation and function of intercellular adhesion molecules (ICAMs). J Biol Chem. 280, 7, 5854-5861 (2005).Abstract
An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin αLβ2. Proc Natl Acad Sci USA 102, 9, 3366-3371 (2005).Abstract
Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering. Proc Natl Acad Sci USA 102, 3679-3684 (2005).Abstract
Two-dimensional kinetics regulation of αLβ2-ICAM-1 interaction by conformational changes of the αL inserted domain. J Biol Chem. 280, 51, 42207-42218 (2005).Abstract
Integrin β3 regions controlling binding of murine mAb 7E3: Implications for the mechanism of integrin αIIbβ3 activation. Proc Natl Acad Sci USA 101, 36, 13114-13120 (2004).Abstract
Activation of integrin β subunit I-like domains by one-turn C-terminal α-helix deletions. Proc Natl Acad Sci USA 101, 8, 2333-2338 (2004).Abstract
Rolling adhesion through an extended conformation of integrin αLβ2 and relation to αI and βI-like domain interaction. Immunity 20, 4, 393-406 (2004).Abstract
The primacy of affinity over clustering in regulation of adhesiveness of the integrin αLβ2. J. Cell Biol. 167, 6, 1241-1253 (2004).Abstract
A specific interface between integrin transmembrane helices and affinity for ligand. PLoS Biol. 2, 6, 776-786 (2004).Abstract
Locking the β3 integrin I-like domain into high and low affinity conformations with disulfides. J. Biol. Chem. 279, 11, 10215-10221 (2004).Abstract
Allosteric β1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain. J. Biol. Chem. 279, 26, 27466-27471 (2004).Abstract
The binding sites for competitive antagonistic, allosteric antagonistic, and agonistic antibodies to the I domain of integrin LFA-1. J. Immunol. 173, 6, 3972-3978 (2004).Abstract
Structural basis for allostery in integrins and binding of fibrinogen-mimetic therapeutics. Nature 432, 7013, 59-67 (2004).Abstract
RIAM, an Ena/VASP and profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Dev. Cell 7, 4, 585-595 (2004).Abstract
The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion. Adv. Prot. Chem. 68, 29-63 (2004).Abstract
Therapeutic antagonists and the conformational regulation of the β2 integrins. Current Topics in Medicinal Chemistry 4, 1485-1495 (2004).Abstract
Boca-dependent assembly of β-propeller/EGF modules in low-density lipoprotein receptor proteins. EMBO J. 23, 6, 1372-1380 (2004).Abstract