The domain structure of ICAM-1 and the kinetics of binding to rhinovirus

Citation:

Casasnovas, J.M., Bickford, J.K. & Springer, T.A. The domain structure of ICAM-1 and the kinetics of binding to rhinovirus. J. Virol. 72, 7, 6244-6246 (1998).

Abstract:

Fragments of intercellular adhesion molecule 1 (ICAM- 1) containing only the two most N terminal of its five immunoglobulin SF domains bind to rhinovirus 3 with the same affinity and kinetics as a fragment with the entire extracellular domain. The fully active two-domain fragments contain 5 or 14 more residues than a previously described fragment that is only partially active. Comparison of X-ray crystal structures show differences at the bottom of domain 2. Four different glycoforms of ICAM- 1 bind with identical kinetics.

Notes:

NIH grant #AI31921Reprint Status: In File

Last updated on 09/30/2015