@article {527756,
	title = {The molecular basis for cytolytic T lymphocyte function: Analysis with blocking monoclonal antibodies},
	journal = {Adv. Exper. Med. Biol.},
	volume = {146},
	year = {1982},
	note = {Reprint Status: In File},
	pages = {447-465},
	abstract = {During the past decade the mechanism of CTL-mediated killing has been resolved into 3 steps, and its cation requirements, and general nature have been well defined. However, biochemical understanding of the CTL-target interaction has made little progress. Recently, we have developed a monoclonal antibody (MAb) which blocks killing by binding to a previously undescribed molecule on the CTL membrane, a molecule which we therefore have termed lymphocyte function-associated antigen one (LFA-1). LFA-1 and Lyt-2,3 are the only presently identified sites for such blocking; antibodies to over a dozen other molecules expressed on the CTL do not block killing. Present evidence suggests that LFA-1 is crucial in the adhesive interaction of T cells with other cells (e.g., targets, macrophages, perhaps B cells) The continuing search for blocking MAbs provides a systematic way to link specific molecules with CTL function.},
	keywords = {G/2,43},
	author = {Martz,E. and Davignon,D. and K{\"u}rzinger,K. and Springer, T.A.}
}
