@article {528086, title = {Integrin avidity regulation: Are changes in affinity and conformation underemphasized?}, journal = {Curr. Opin. Cell Biol.}, volume = {15}, number = {5}, year = {2003}, note = {in file}, pages = {547-556}, abstract = {Integrins play critical roles in development, wound healing, immunity and cancer. Central to their function is their unique ability to modulate dynamically their adhesiveness through both affinity- and valency-based mechanisms. Recent advances have shed light on the structural basis for affinity regulation and on the signaling mechanisms responsible for both affinity and valency modes of regulation.}, author = {Carman, C. V. and Springer, T.A.} }