@article {529931,
	title = {ICAM-1 a ligand for LFA-1 dependent adhesion of B, T and myeloid cells},
	journal = {Nature},
	volume = {331},
	number = {6151},
	year = {1988},
	note = {MS $\#$155Reprint Status: In File},
	pages = {86-88},
	abstract = {Cell-cell adhesion is essential for many immunological functions. The LFA-1 molecule, a member of a superfamily of adhesion molecules, participates in adhesion which is critical to the function of each of the three major subsets of leukocytes: lymphocytes, monocytes and granulocytes. Putative LFA-1 ligands have been identified functionally in different laboratories using three different monoclonal antibodies that inhibit LFA-1-mediated leukocyte adhesion in particular model systems; however, there may be more than one LFA-1 ligand. We have directly compared the three relevant monoclonal antibodies, and show that each binds to the same molecule, intercellular-adhesion molecule-1 (ICAM-1). Most important, B, T and myeloid cells adhere specifically to purified ICAM-1-coated surfaces; such adhesion has distinctive requirements for Mg2+ and Ca2+. This constitutes biochemical evidence that ICAM-1 functions as a ligand for LFA-1-dependent adhesion by a variety of leukocytes.},
	author = {Makgoba,M.W. and Sanders,M.E. and Luce,G.E.G. and Dustin,M.L. and Springer, T.A. and Clark,E.A. and Mannoni,P. and Shaw,S.}
}
