%0 Journal Article %J Curr. Opin. Cell Biol. %D 2003 %T Integrin avidity regulation: Are changes in affinity and conformation underemphasized? %A Carman, C. V. %A Springer, T.A. %X

Integrins play critical roles in development, wound healing, immunity and cancer. Central to their function is their unique ability to modulate dynamically their adhesiveness through both affinity- and valency-based mechanisms. Recent advances have shed light on the structural basis for affinity regulation and on the signaling mechanisms responsible for both affinity and valency modes of regulation.

%B Curr. Opin. Cell Biol. %V 15 %P 547-556 %G eng %N 5 %! Curr. Opin. Cell Biol. %F 461