β2 Integrin
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β2 Integrin Researchers
Mehmet Sen, Ph.D.
msen2@central.uh.eduAssistant Professor, Biology and Biochemistry Department, University of Houston
Travis Moore, Ph.D.
Assistant Professor, Integrative Biology and Pharmacology, Director, Center for Advanced Microscopy, McGovern Medical School - University of Texas Health Sciences, Houston, Texas
Recent Publications
2025
Watson, S. M., Harvey, E. P., Pishesha, N., Ploegh, H. L. & Springer, T. A. Nanobodies targeting EGFR provide insight into conformations stabilized by glioblastoma mutations. The Journal of biological chemistry 110374 (2025) doi:10.1016/j.jbc.2025.110374.
Watson, S. M., Harvey, E. P., Pishesha, N., Ploegh, H. L. & Springer, T. A. Nanobodies targeting EGFR provide insight into conformations stabilized by glioblastoma mutations. The Journal of biological chemistry 110374 (2025) doi:10.1016/j.jbc.2025.110374.
Wang, X. et al. De novo design of integrin α5β1 modulating proteins to enhance biomaterial properties. Adv Mater (2025) doi:10.1002/adma.202500872.
Wang, X. et al. De novo design of integrin α5β1 modulating proteins to enhance biomaterial properties. Adv Mater (2025) doi:10.1002/adma.202500872.
2024
Li, J. et al. Ligand binding initiates single-molecule integrin conformational activation. Cell 187, 2990–3005.e17 (2024).
Li, J. et al. Ligand binding initiates single-molecule integrin conformational activation. Cell 187, 2990–3005.e17 (2024).
2023
Roy, A. et al. De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8. Nat Commun 14, 5660 (2023).
Roy, A. et al. De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8. Nat Commun 14, 5660 (2023).
2022
Jo, M. H. et al. Single-molecule characterization of subtype-specific β1 integrin mechanics. Nat Commun 13, 7471 (2022).
Jo, M. H. et al. Single-molecule characterization of subtype-specific β1 integrin mechanics. Nat Commun 13, 7471 (2022).
Lin, F.-Y. et al. A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell 185, 3533–3550.e27 (2022).
Lin, F.-Y. et al. A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell 185, 3533–3550.e27 (2022).