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  • [NEWS] UC Berkeley MCB Commencement Address 2022 - Tim Springer

  • 2022-05_{Bonazza, 2022 #38029}

    LATEST in eLife

    "VWF A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N- and C-linker"

  • {Jiang, 2022 #37950}

    LATEST in Cancer Immunology Research

    "Loss of LRRC33-dependent TGFβ1 activation enhances antitumor immunity and checkpoint blockade therapy"

  • {Anderson, 2022 #37926}

    LATEST in Molecular Biology of the Cell

    "Regulation by metal ions and the ADMIDAS of integrin α5β1 conformational states and intrinsic affinities"

  • Figure 5 - Le 2022

    LATEST in JMB

    "Protection of the prodomain α1-helix correlates with latency in the transforming growth factor-β family"

  • group photo of 2022 Springer Lab members

    We're Hiring!

    Click for a description of available postdoctoral projects.


We study receptor-ligand interactions and transmembrane signal transmission that are relevant to immunology, hemostasis, and human disease using structural, cell biological, and single molecule techniques. A unifying theme is how force interacts with protein conformational change to activate integrins, von Willebrand factor, transforming growth factor-beta family proteins, and adhesins on malaria sporozoites.

Latest News

  • [HIRING]: Postdoctoral Fellow Positions
  • Tim Springer delivers UC Berkeley's MCB 2022 Commencement Address
  • Timothy A. Springer to Receive Biophysical Society’s 2022 Founders Award [Biophysical Society]
  • [CLOSED]: Research Assistant I (2021)
  • Point Man On Protein Science [In Vivo]
  • Harvard's Billionaire in a Lab Coat [Harvard Crimson]
More

Connect with the Springer Lab

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