News

NEW PAPER: Force-induced on-rate switching and modulation by mutations in gain-of-function von Willebrand diseases.

April 14, 2015

Jongseong Kim, Nathan E. Hudson, and Timothy A. Springer

Abstract

Mutations in the ultralong vascular protein von Willebrand factor (VWF) cause the common human bleeding disorder, von Willebrand disease (VWD). The A1 domain in VWF binds to glycoprotein Ibα (GPIbα) on platelets, in a reaction triggered, in part, by alterations in flow during bleeding. Gain-of-function mutations in A1 and GPIbα in VWD suggest conformational regulation. We report that force application switches A1 and/or GPIbα to a second state with faster on-...

Read more about NEW PAPER: Force-induced on-rate switching and modulation by mutations in gain-of-function von Willebrand diseases.

NEW PAPER: Structure of bone morphogenetic protein 9 procomplex.

March 24, 2015

Li-Zhi Mi, Christopher T. Brown,Yijie Gao, Yuan Tian, Viet Q. Le, Thomas Walz, and Timothy A. Springer

Abstract

Bone morphogenetic proteins (BMPs) belong to the TGF-β family, whose 33 members regulate multiple aspects of morphogenesis. TGF-β family members are secreted as procomplexes containing a small growth factor dimer associated with two larger prodomains. As isolated procomplexes, some members are latent, whereas most are active; what determines these differences is unknown. Here, studies on pro-BMP structures and binding to receptors...

Read more about NEW PAPER: Structure of bone morphogenetic protein 9 procomplex.

Dr. Timothy Springer receives the 2014 Henry M. Stratton Medal

July 22, 2014
The American Society of Hematology Honors Geraldine P. Schechter, MD, and Timothy Springer, PhD, with 2014 Henry M. Stratton Medal

Published on: July 22, 2014

(WASHINGTON, July 22, 2014) – The American Society of Hematology (ASH) today announced that it will recognize Geraldine P. Schechter, MD, of the Washington Veterans Affairs Medical Center and George Washington University, and Timothy Springer, PhD, of Harvard Medical School,...

Read more about Dr. Timothy Springer receives the 2014 Henry M. Stratton Medal